Statins have been promoted as a wonderdrug that cures just about anything. Which brings to mind the old adagio: When something sounds to good to be true, it’s to good to be true.
The latest offering of statins preventing venous thrombosis has been checked and falsified
In the absence of any randomised trials with venous thrombosis as the primary endpoint, Rahimi and colleagues present a pooled analysis of 29 randomised studies, all with primary endpoints other than venous thrombosis. Only in two studies had venous thrombotic events been presented in the published report, but they had been recorded as adverse events in all other trials, too, and these data were made available to the authors. When comparing statin users with non-users in the meta-analysis, venous thrombosis occurred in 0.9 per 1,000 in statin users versus 1.0 per 1,000 in non-users, for an odds ratio of 0.89 (95% confidence interval 0.78–1.01). When the study prompting this analysis (JUPITER, ) was excluded, the odds ratio became 0.93 (95% CI, 0.82–1.07). Whereas these results perhaps still suggest a small effect, no effect whatsoever was observed in trials comparing high versus low dose statins.
In other words, even if there is an effect it’s so small it doesn’t merit the risk of taking statins with their harmful sideeffects